Toxicology SIG



To provide a forum to discuss the statistical issues involved in Regulatory and Investigative Toxicology.


Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in pre-clinical areas such as:

- Acute Tox
- General Tox
- Toxicokinetics
- Repro Tox
- Genetic Tox
- Immuno Tox
- Toxicogenomics
- Histopathology
- Safety Pharmacology
- Carcinogenicity

We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list.

How to get in touch

Join our mailing list by e-mailing this address with brief details of the field(s) you are working in.  

Latest News

We are excited to announce that we will be running a workshop in 2019. It will be on the 2nd and 3rd April at the Crowne Plaza Hotel near Heathrow . Watch this space for more information!

Upcoming Events

The PSI Special Interest Group “Toxicology” have a series of regular FREE webinars dealing with statistical topics faced in toxicology and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this years seminars.


Since our inauguration in 2006 we have run a workshop approximately every 18 months. Our last workshop was run on the 24-25 April 2018 at the Crowne Plaza Hotel near Heathrow. The agenda focused on five topics: 

  • Self admin/abuse potential
  • Statistical methods for analysing the Ames-test
  • Role of the  Non-Clinical Statistician
  • Bio-Assay Validation
  • Statistics in Safety Testing
You can find all the slides under the PSI Resources page searching for: > Toxicology Sig > TOX SIG Workshop 2018 



The PSI Special Interest Group “Toxicology” seminars for 2019 are as follows: 




19 Feb 2019

Data Quality and Pre-Clinical Research

Malcolm Macleod

16 April 2019

ICH S1 revision and CAD process


18 June 2019

17 Sept 2019

10 Dec 20019


To Register for a webinar please click on the link once it is available.

For all previous webinars click here.


Latest News

Show all news

EventsFuture Events

  • PSI Toxicology SIG Workshop 2019 - Dates: 02 – 03 Apr, 2019

    This 1.5-day workshop will involve approximately 20 statisticians, focusing on discussions around “best practice” in the statistical analysis of various data types.​
  • PSI Journal Club: Missing Data - Dates: 24 – 24 Jan, 2019

    Our next journal club, held jointly with the DIA, features two papers on the topic of Statistical Considerations for Innovative Designs in Clinical Trials. Please join us to hear Jason Yuan and Xiangmin Zhang present their recent work.

Principal Statistician


Resized PAREXEL Logo with Tagline_Small_Full Color

Senior/Principal Biostatistician



Statistician for HTA/Medical Affairs (contractor and permanent)



Associate / Senior / Principal Statistical Scientist positions