Toxicology SIG

Objectives

 

To provide a forum to discuss the statistical issues involved in Regulatory and Investigative Toxicology.

 

Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in pre-clinical areas such as:

- Acute Tox
- General Tox
- Toxicokinetics
- DMPK
- ECG
- Repro Tox
- Genetic Tox
- Immuno Tox
- Toxicogenomics
- Histopathology
- Safety Pharmacology
- Carcinogenicity

We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list.
 

How to get in touch

Join our mailing list by e-mailing this address with brief details of the field(s) you are working in.  



Latest News

We are excited to announce that we will be running a workshop in 2019. It will be on the 2nd and 3rd April at the Crowne Plaza Hotel near Heathrow .

The topics selected for the agenda this year include:

  • Bayesian approaches in pre-clinical
  • Brainstorming to prepare a paper on statistical approaches in Toxicology/Safety Assessment studies
  • Translation between pre-clinical and clinical
  • Exploration of new areas where we can have an impact (eg Data Sciences, Big Data, Machine Learning…)

All this, including overnight accommodation, dinner, breakfast and refreshments during the 2 days, is available for £205 per delegate.

 

Registration is open and spaces are limited.


To Register click here



Upcoming Events

The PSI Special Interest Group “Toxicology” have a series of regular FREE webinars dealing with statistical topics faced in toxicology and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this years seminars.


Workshops

Since our inauguration in 2006 we have run a workshop approximately every 18 months. Our last workshop was run on the 24-25 April 2018 at the Crowne Plaza Hotel near Heathrow. The agenda focused on five topics: 

  • Self admin/abuse potential
  • Statistical methods for analysing the Ames-test
  • Role of the  Non-Clinical Statistician
  • Bio-Assay Validation
  • Statistics in Safety Testing
You can find all the slides under the PSI Resources page searching for: > Toxicology Sig > TOX SIG Workshop 2018 

 
 

Webinars

The PSI Special Interest Group “Toxicology” seminars for 2019 are as follows: 

Date

Title

Presenter

19 Feb 2019

Data Quality and Pre-Clinical Research

Professor Malcolm Macleod     

16 April 2019

ICH S1 revision and CAD process

TBC

18 June 2019

The Pig-a-Assay

Scientist(s) from Covance

17 Sept 2019

10 Dec 2019

 

To Register for a webinar please click on the link once it is available.

For all previous webinars click here.

 

Latest News


Show all news

EventsFuture Events


  • Webinar: MCP-Mod – Theory, Implementation and Extensions - Dates: 08 – 08 May, 2019

    MCP-Mod (Multiple Comparisons & Modelling) is a popular statistical methodology for model-based design and analysis of dose finding studies. This webinar will describe the theory behind MCP-Mod (plus extensions), and how to implement it within available software. Pantelis Vlachos (Cytel) will provide a brief introduction to the methodology and illustrate the MCP-MoD capabilities in EAST 6.5. Saswati Saha (University of Brehem) will discuss new variations and alternatives to MCP-Mod and show how to implement them in R. Neal Thomas (Pfizer) will present further technical details of MCP-Mod by evaluating the method using results from least squares linear model theory.
  • PSI Toxicology SIG Workshop 2019 - Dates: 02 – 03 Apr, 2019

    This 1.5-day workshop will involve approximately 20 statisticians, focusing on discussions around “best practice” in the statistical analysis of various data types.​