Benefit-Risk SIG

The Benefit-Risk SIG was set up at the start of 2012 to help support those involved in this fast evolving area.

The main aims of the SIG are:

• To understand how best to apply Benefit-Risk methodologies across the Pharmaceutical Industry
• To discuss and make recommendations on key methodological issues
• To share examples of how Benefit-Risk has been used within pharmaceutical companies
• To share external information including new developments around Benefit-Risk

Currently the SIG has subgroups working on:
• Literature review
• Benefit-Risk in the HTA setting (together with the HTA SIG)
• Bayesian applications in Benefit-Risk
• Preference elicitation and  Benefit-Risk

We also develop relevant training in the area of structured  Benefit-Risk as needed.

If you have an interest in being involved in this SIG, or have an interesting case study or experience of carrying out a structured Benefit-Risk assessment to share, please contact Maria Costa (email:

Our BLOG can be found under It is a great source of information for all things Benefit-Risk related: upcoming conferences, journal publications, training, and much more.

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EventsFuture Events

  • PSI Toxicology SIG Workshop 2019 - Dates: 02 – 03 Apr, 2019

    This 1.5-day workshop will involve approximately 20 statisticians, focusing on discussions around “best practice” in the statistical analysis of various data types.​
  • PSI Journal Club: Missing Data - Dates: 24 – 24 Jan, 2019

    Our next journal club, held jointly with the DIA, features two papers on the topic of Statistical Considerations for Innovative Designs in Clinical Trials. Please join us to hear Jason Yuan and Xiangmin Zhang present their recent work.

Principal Statistician


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Senior/Principal Biostatistician



Statistician for HTA/Medical Affairs (contractor and permanent)



Associate / Senior / Principal Statistical Scientist positions