Past PSI Events

Conferences

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Scientific Meetings

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Training Courses

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Journal Club

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Webinars

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Careers Meetings

PSI Toxicology SIG Webinar

Time: 14:00 - 15:00 UK Time
Presenter: Dr Bernd-Wolfgang Igl

Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.

Dr Bernd-Wolfgang Igl

Statistical Analysis of the Comet assay

Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany

The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.   

Please click here to view the slides.

To access the recording, please visit the Video-on-Demand Library.

Upcoming Events

PSI VisSIG Wonderful Wednesdays

Our monthly webinar explores examples of innovative data visualisations relevant to our day to day work. Each month a new dataset is provided from a clinical trial or other relevant example, and participants are invited to submit a graphic that communicates interesting and relevant characteristics of the data.

PSI VisSIG Webinar: Rapid Insights to Data

The field of data visualization is the intersection of data journalism, statistics, graphic design, computer science, neuroscience, and cognitive psychology. We will focus on the latter two fields of data visualization as it relates to data visualization: neuroscience and cognitive psychology.

PSI One-Day Meeting: Non-proportional hazards and applications in immuno-oncology

Hear about potential strategies to handle non-proportional hazards and delayed treatment effects from experts in the field.

PSI One-Day Meeting: Missing Data in Clinical Trials - Past, Present and Future

At this meeting we will present the evolution of missing data approaches, looking at how they have been handled in the past, the current established missing data approaches and the impact of the new ICH E9 R1 addendum on the handling of missing data, focussing in particular on the treatment policy estimand.

PSI Training Course: R for SAS Users

R is quickly gaining popularity within the pharmaceutical industry due to it being a very powerful object-orientated language, and is able to produce analyses and high quality graphics. This will be a hands-on interactive course and will utilise the RStudio Cloud development environment.

PSI Webinar: Oncology Ted Talks (with interaction)

The format of this event will include Ted Talks by all of our speakers with the opportunity for us to have a discussion together after each of the presentations.

PSI EIWG Webinar: Estimands in Oncology - How and Why

A year on after the final ICH E9 estimands addendum was published, we bring estimands to life. Members of the Estimands in Oncology special interest group will describe how the estimand framework provides a common language to describe the diversity of patient journeys and why it is important to address the right question in clinical trials.

PSI Training Course: Data Monitoring Committees (DMCs)

This course will cover the essentials of DMC set up (roles and responsibilities, DMC charter, practical considerations), as well as discussing DMC case studies and the role of DMCs in adaptive trials and during the pandemic. In addition, there will be an interactive DMC workshop.

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