Event

PSI Training Course: Multiple Testing in Confirmatory Clinical Trials

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This course will focus on the principles underlying multiple comparison procedures and their applications to confirmatory clinical trials. We will describe simple ways to construct valid multiple tests, and will explore how tests can be incorporated into recycling strategies.

To be presented by Carl-Fredrik Burman & Lisa Hampson

Regulatory agencies require strong control of the Type I Error for all confirmatory statistical tests. Multiplicity issues can arise for several reasons, e.g.: the possibility of winning on two different endpoints (like PFS and OS), interim analyses, or testing for effects in several patient groups. This course will focus on the principles underlying multiple comparison procedures and their applications to confirmatory clinical trials. We will describe simple ways to construct valid multiple tests, and will explore how tests can be incorporated into recycling strategies. Group-sequential and some common adaptive tests will also be described. Concepts will be introduced through a combination of lectures, exercises, and discussion sessions where groups will focus on the issues that might be encountered when designing and communicating statistical tests.

The following topics will be covered:

  • Introduction to Multiple Testing
  • Recycling and graphical methods
  • Group sequential and adaptive designs
  • Operating characteristics and improving them using correlations
  • Using decision analysis to optimise multiple testing procedures

Registration

  Early bird (up to & including 9th April)  After 9th April
PSI Member  £295 + VAT  £345 + VAT
Non-Member  £390 + VAT  £440 + VAT

Registration is now closed.

Registration costs include lunch and refreshments. PSI are holding a limited number of hotel rooms on 8th May which will be allocated on a first come first served basis. Please contact psi@mci-group.com to reserve a room. Rooms are charged at £109.00 per room including breakfast.

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