Pre-Clinical SIG (previously TOX SIG) 



Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (former member and chair), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (chair, GlaxoSmithKline), Jim Saul (Covance) and Phillip Jarvis (Novartis). Luc Essermeant (Sanofi) and Ezgi Tanriver-Ayder (GlaxoSmithKline) have also recently joined the team.



To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.


Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity


We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:

Upcoming Events

The PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars. 


21 June 2022- 14:00 BST|15:00 CEST

Dr Francq will discuss the need for analytical methods to deliver unbiased and precise results and talk in detail on confidence, prediction and tolerance intervals work in linear mixed models and the interpretation of statistical results. Attendees will learn about robust assay qualification methodology. 

This will be followed by Q&A.



The PSI Pre-Clinical Special Interest Group seminars for 2022 are as follows: 





12 April

Optimal Experimental Design in Preclinical Dose Response Studies

Dr. Tim Holland-Letz, DKFZ

For more information and to register please click here

21 June

Regression to the mean, dilution and bridging studies illustrated in R

Dr. Bernard Francq, GSK

For more information and to register please  click here
4 October

Therioepistemology: Rethinking how we conduct animal-based experimentation

Dr. Brianna Gaskill, NovartisMore information pending

For all previous webinars click here.



We are planning to hold our 10th and first fully virtual 1.5 day workshop on 19/20 September, 2022.

DateTitle Presenter 
19/20 Sept

Workshop including a short course on the application of Bayesian Methods in Preclinical Environment

Bruno Boulanger, PharmaLexMore information pending




How to get in touch

Please email us with any questions or comments and if you would like to join our mailing list.


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