Pre-Clinical SIG (previously TOX SIG) 

 

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Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (former member and chair), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (chair, GlaxoSmithKline), Jim Saul (Covance) and Phillip Jarvis (Novartis). Luc Essermeant (Sanofi) and Ezgi Tanriver Ayder (Astrazeneca) has also recently joined the team.

 

Objectives

To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.

 

Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- ECG
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity

 

We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:

 

Upcoming Events

The PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars.

Webinars

The PSI Pre-Clinical Special Interest Group seminars for 2021 are as follows: 

Date

Title

Presenter

Video on Demand

16 Mar

Beyond the looking glass – Interpreting animal welfare & behaviour by monitoring & assessing mice activity data

Eloisa Brook, Joanna Moore, George Birbeck. GSK

VoD

29 Jun

Update from the Carcinogenicity working group

Steve Bailey. Pfizer

VoD

For all previous webinars click here.

 

Workshop

We are planning to hold our 10th and first fully virtual workshop on 4 and 5 April, 2022.

 

 

How to get in touch

Please email us with any questions or comments and if you would like to join our mailing list.


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Upcoming Events

PSI Book Club

PSI are starting a book club! We will be reading/discussing non-technical books relevant to our roles. Participants will be split into smaller groups to network with each other and practice exercises.

PSI VisSIG Wonderful Wednesday Webinar Series

This is a good opportunity to develop your knowledge by thinking through a practical example, practicing how to apply graphics principles, and developing your coding skills.

PSI Webinar: Tipping Point Analyses - Introduction & Case Studies

What is a tipping point analysis, and how is one performed? What are the different approaches for continuous, binary and time to event data? Our speakers will present and discuss some practical examples.

PSI Careers - MEDMathS: Medicine Empowered by Data, Maths and Statistics

In just 1 hour, learn about the field of medical statistics and how it plays a crucial role in developing ground-breaking new medicines, vaccines and healthcare products.

PSI Medical Statistics Careers Event

Our annual PSI Medical Statistics Careers Event, will be held online on Wednesday 2nd March 2022. The event will include a live online panel discussion and a virtual exhibition session.

PSI Training Course: Simulation of Clinical Trials using Tidyverse

In this course, we introduce a framework for clinical trial simulations that makes extensive use of the tidyverse collection of R packages.

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