Pre-Clinical SIG

We are a group of statisticians working at CROs and pharmaceutical industry supporting preclinical drug discovery on animal and cell based experiments. As a group, our focus is on diverse range of preclinical topics such as;

  • Discovery
  • Robust study design/good statistical practices in in-vitro, ex-vivo and in-vivo assay development
  • Reproducibility and Translation from pre-clinical to clinical
  • Toxicogenomics
  • General Toxicology
  • Eco-Toxicology
  • Toxicokinetics
  • DMPK / Pharmacokinetics
  • ECG
  • Immuno Toxicology
  • Histopathology
  • Pharmacology
  • Developmental and Reproductive Toxicology
  • Carcinogenicity


We organise webinars and workshops on topics and methodological developments in preclinical research and now have a list of over 50 affiliates on our e-mail distribution list. 



CC 3  Core Committee (L-R): 

  Denise FedericoEvotec   
  Luc Essermeant Sanofi
  Eloisa BrookGSK (chair)
  Dorothee Tamarelle Sanofi
  Fetene TekleJanssen
  Bernd Igl

Boehringer Ingelheim

  Ezgi Tanriver-Ayder


  Sarah VandepaerGSK





We see our mission as bridging preclinical knowledge and expertise within the pharmaceutical industry and academia to provide a forum to collaborate, discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment. We also hope to encourage the development of relevant statistical methodologies and promote the involvement of statisticians in these areas.

Find out more about us and our objectives in our video overview:


Upcoming Pre-Clinical SIG 2024 Webinar

PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars. Please note that these events take place online via Zoom, and have a limited number of places available. 


The PSI Pre-Clinical Special Interest Group seminars for 2024 are as follows: 





26 March 2024

Mixed-Level OMARS Designs for Quantitative and Categorical Factors: Theory and Application

Professor Peter Goos, KU Leuven 

To access video on demand, click here

Workshop 2024, Paris

We held our first face-to-face workshop since 2019 in Paris this year. It was wonderful to connect with old and new faces.There was great engagement in the sessions; we all learnt something and had fun too!





Application of experimental design in animal research: theory and practice 

Simon Bate, GSK

2Analysing Pre-clinical experiments 

Odile Coudert, Ipsen & Bernard Franq, GSK

 Statistics in Toxicology 

Philip Jarvis, Novartis & David Lovell, University of London



Workshop 2024



How to get in touch

Please email us if you are interested in contributing to PSI Preclinical SIG or would like to join our mailing list.


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