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Expert in Clinical Trial Methodology

Astrazeneca

Overview

Location: Cambridge, Gaithersburg or Gothenburg

Are you a Statistician – experienced or in the beginning of your career? Do you have an appetite to use statistical methods to develop life-changing medicines? If you would like to apply your expertise in a global company pushing the boundaries of science – join us!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person

We’re driving leading-edge approaches to drug development across many business areas – within Early Biometrics & Statistical Innovation (EB&SI) a data-centric focus is helping us work more efficiently and creatively to bring the right medicines to the right patients.

Our biometrics and innovation teams use their expertise in statistics and programming to answer drug development objectives and reduce uncertainty in product development, driving better business decisions with quantitative reasoning.

You will sit within our Statistical Innovation group in EB&SI, which is a methodological hub for statistical design and analysis of clinical trials. Working as part of Data Science and AI, you’ll be able to access technology at the forefront of science in an innovative environment, where you will have the scope to develop creative statistical ideas and approaches, and to apply them in your work.

Main duties & responsibilities

Joining a team of statistical methodology experts, you will provide key input as you work to find solutions to problems at critical stages in the drug development cycle.

This is exciting and technically challenging work in a dynamic and constantly changing landscape. Your key focus will be on producing pragmatic solutions, often within a tight time scale where the emphasis will be to deliver first, then refine and develop your solutions thereafter.

You will contribute to, or lead capability build in more than one of the following statistical areas:  

Methods to analyse data collected in real-time, Estimands, Missing Data, Subgroups and Biomarkers.

You will also provide expert consultancy on key issues for fellow statisticians working in our therapeutically aligned statistics groups, as well as medical scientists and other key roles across the business. This will involve leading and participating in strategic activities such as capability build projects, which can directly impact improvements to the way clinical trials are designed and analysed in AstraZeneca. As well as developing and implementing new methodology, interacting with external scientists and regulators, through publications, presentations and cross-industry collaborations. There will also be a focus proactively identify new areas where Statistical Innovation can add value, developing collaborative relationships with the external scientific/academic community.

Requirements

Essential

  • PhD in Statistics or a related discipline, followed by experience of independent academic research and/or clinical drug development
  • Documented ability of delivering innovative statistical solutions in an applied environment (related to at least one of the following areas: Analysis of data collected in real-time (e.g. sensor data), Missing data, Subgroups and Biomarkers and Estimands
  • Strong knowledge of programming in R and/or SAS
  • High level of competence in global and cross-skilled collaborative working
  • Track record of research and methodological development in Statistics, supported by scientific publications in first class statistical journals
  • Desire to apply your scientific competence on practical problems, for the benefit of patients

Desirable

  • Knowledge / research experience in the development of statistical methodology related to the analysis and interpretation of safety data, observational studies, meta-analysis, Bayesian statistics, non-linear and mixed effect models.
  • Broad awareness of statistical issues against the evolving scientific and regulatory landscape

In addition to be considered for appointment at the more senior level, the documented ability to deliver innovative statistical solutions should be in at least 2 of the areas listed above or be a recognised expert in one of these areas and an extensive publication record would be expected.

Why AstraZeneca?

At AstraZeneca, when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, groundbreaking cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

How to apply

We would like to know more about you. If you are interested, visit our website to apply now!