BEGIN:VCALENDAR
VERSION:2.0
METHOD:PUBLISH
PRODID:-//Telerik Inc.//Sitefinity CMS 15.4//EN
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
DTSTART;VALUE=DATE:20250101
TZNAME:UTC
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DESCRIPTION:The next PSI Toxicology SIG webinar is on the 12th December at 
 14:00 GMT.\nThomas Jaki is presenting about &ldquo\;Optimal designs for no
 n-compartmental PK studies&rdquo\;.\nIn traditional PK/PD trials\, pharmac
 okinetics (PK) is investigated in the satellite group of animals\, and the
  pharmacodynamics (PD) is investigated in the study group of animals. The 
 new blood sampling method of microsampling opens up the opportunity to inv
 estigate both PK and PD in the same animals. To avoid excessive burden on 
 the animals from the required blood sampling\, sparse sampling schemes are
  typically utilized. Motivated by this application\, this talk introduces 
 a procedure to choose an optimal sparse sampling scheme and sampling time 
 points using non-compartmental methods but which can be applied to further
  settings beyond this. We discuss how robust designs can be obtained and w
 e apply and evaluate the approach to a range of scenarios to give an examp
 le of how it may be implemented. The results are compared to optimal desig
 ns for model based PK.\n\nClick here&nbsp\;to view the presentation slides
 .\n\nTo access the recording\, please visit the Video-on-Demand Library.
DTEND:20171212T150000Z
DTSTAMP:20260511T194407Z
DTSTART:20171212T140000Z
LOCATION:
SEQUENCE:0
SUMMARY:PSI Toxicology SIG Webinar 
UID:RFCALITEM639141254473194446
X-ALT-DESC;FMTTYPE=text/html:<p>The next PSI Toxicology SIG webinar is on t
 he 12th December at 14:00 GMT.</p>\n<p>Thomas Jaki is presenting about &ld
 quo\;Optimal designs for non-compartmental PK studies&rdquo\;.</p>\n<p>In 
 traditional PK/PD trials\, pharmacokinetics (PK) is investigated in the sa
 tellite group of animals\, and the pharmacodynamics (PD) is investigated i
 n the study group of animals. The new blood sampling method of microsampli
 ng opens up the opportunity to investigate both PK and PD in the same anim
 als. To avoid excessive burden on the animals from the required blood samp
 ling\, sparse sampling schemes are typically utilized. Motivated by this a
 pplication\, this talk introduces a procedure to choose an optimal sparse 
 sampling scheme and sampling time points using non-compartmental methods b
 ut which can be applied to further settings beyond this. We discuss how ro
 bust designs can be obtained and we apply and evaluate the approach to a r
 ange of scenarios to give an example of how it may be implemented. The res
 ults are compared to optimal designs for model based PK.<br />\n<br />\nCl
 ick <a href="https://www.psiweb.org/docs/default-source/default-document-l
 ibrary/tox_sig_2017-presentation-slides.pdf?sfvrsn=e0a5dfdb_0&sf_site_temp
 =true&sf_site=00000000-0000-0000-0000-000000000000" title="here">here</a>&
 nbsp\;to view the presentation slides.<br />\n<br />\n<strong>To access th
 e recording\, please visit the <a href="https://www.psiweb.org/vod">Video-
 on-Demand Library</a>.</strong></p>
END:VEVENT
END:VCALENDAR