Toxicology SIG

Our mission statement:

To provide a forum to discuss the statistical issues involved in Regulatory and Investigative Toxicology.


Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in preclinical areas such as:

- Acute Tox
- General Tox
- Toxicokinetics
- DMPK
- ECG
- Repro Tox
- Genetic Tox
- Immuno Tox
- Toxicogenomics
- Histopathology
- Safety Pharmacology
- Carcinogenicity

We discuss topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and no have a list of over 40 affiliates on our e-mail distribution list.
 
Join our mailing list by e-mailing this address with brief details of the field(s) you are working in.

Workshops

In March 2017 we ran our latest Workshop, at the Crowne Plaza Hotel near Heathrow. The agenda focused on five hot topics in Toxicology: 

  • Repeated measures for Toxicology
  • Historical Control Data/outliers/control charts
  • Outlier determination
  • Carcinogenicity studies
  • How do we empower scientists to do routine analyses, whilst still ensuring quality of results?

Since our inauguration in 2006 we have run these workshops approximately every 18 months. We plan on running the next workshop on the 24th and 25th April 2018 at the Crowne Plaza Hotel, Heathrow, UK. More details to follow shortly.
 

 

Recent Activity 

The PSI Special Interest Group “Toxicology” have a series of regular webinars dealing with statistical topics faced in toxicology and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time.

 

The webinars we have planned are:

 

Date

Title

Presenter

19th Sept 2017

Statistics and the Ames Test

David Lovell

12th Dec 2017

Optimal designs for non-compartmental PK studies

Thomas Jaki

20th Feb 2018

TBC

17th Apr 2018

Comet Assay

Bernd-Wolfgang Igl

19th Jun 2018

TBC

18th Sept 2018

TBC

 

 

 

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EventsFuture Events


  • PSI Toxicology SIG Workshop 2018 - Dates: 24 – 25 Apr, 2018

    The Toxicology SIG provides a forum for statisticians working in regulatory and investigative toxicology to discuss issues and interact with one another. This 1.5-day workshop will involve hopefully approximately 20 statisticians, focusing on discussions around “best practice” in the statistical analysis of various data types.
  • PSI Toxicology SIG Webinar - Dates: 12 – 12 Dec, 2017

    This talk introduces a procedure to choose an optimal sparse sampling scheme and sampling time points using non-compartmental methods but which can be applied to further settings beyond this. We discuss how robust designs can be obtained and we apply and evaluate the approach to a range of scenarios to give an example of how it may be implemented.
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